I can't do them on the last full day of my trip. Huge mistake for me personally with regard to traveling and not feeling very well. Early is better imo.
We did it one on our last full day last year. I was so nervous about getting hung over for travel the next day. They were pretty good when I said ‘No thanks’ for a refill... Everything ended well, and I ended the trip with a great buzz and wasn’t hungover.